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NEUROFIBRILLARY TANGLES
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DeCS
Descriptor
English
:
Neurofibrillary Tangles
Descriptor
Spanish
:
Ovillos Neurofibrilares
Descriptor
Portuguese
:
Emaranhados Neurofibrilares
Synonyms
English
:
Neurofibrillary Tangle
Tangle, Neurofibrillary
Tangles, Neurofibrillary
Tree Number:
A08.675.609.520
A11.284.430.214.190.750.640.520
A11.671.573.520
Definition
English
:
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and
microtubules
). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following
proteins
: (1) the
intermediate filaments
: medium- and high-molecular-weight neurofilaments; (2) the
microtubule-associated proteins
map-2 and tau; (3) actin; and (4)
UBIQUITINS
. As one of the hallmarks of
ALZHEIMER DISEASE
, the
neurofibrillary tangles
eventually occupy the whole of the
cytoplasm
in certain classes of cell in the
neocortex
,
hippocampus
,
brain stem
, and
diencephalon
. The number of these tangles, as seen in post mortem
histology
, correlates with the degree of
dementia
during life. Some studies suggest that tangle
antigens
leak into the systemic circulation both in the
course
of normal aging and in cases of
Alzheimer disease.
See Related
English
:
Diffuse Neurofibrillary Tangles with Calcification
Neurofibrils
Neurofilament Proteins
Tauopathies
History Note
English
:
92
Allowable Qualifiers
English
:
CH
chemistry
CL
classification
DE
drug effects
EN
enzymology
GE
genetics
IM
immunology
ME
metabolism
MI
microbiology
PS
parasitology
PA
pathology
PH
physiology
RE
radiation effects
TR
transplantation
UL
ultrastructure
VI
virology
Record Number:
29933
Unique Identifier:
D016874
Occurrence in VHL
:
Similar:
DeCS